Decreased ADC precedes cellular swelling in N-Methyl-D-Aspartate (NMDA) treated mouse retina

نویسندگان

  • C-W. Chiang
  • J. Chen
  • S-K. Song
چکیده

Introduction Acute excitotoxicity causes cytotoxic edema that precedes neuron cell necrosis and apoptosis in neurological diseases. Apparent diffusion coefficient (ADC) decreases early reflecting cytotoxic edema in various brain injuries. Our recent study demonstrated that high-resolution diffusion MRI detected three retinal layers of distinct ADC. In this study, we examined the feasibility of detecting Nmethyl-D-aspartate (NMDA) induced retinal excitotoxic injury in mice using in vivo diffusion MRI.

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تاریخ انتشار 2009